User report: https://discord.com/channels/477106835862716416/477391201708802058/786084890613383168
I might be having a similar issue here. My ledger can connect to the web app but can only sign ether transfers. For some reason it can't do other smart contract transactions like creating a new Safe, adding an owner, adding a spending limit, etc. The web app directly rejects those request. (my contract data is activated)
Expected:
Observed:
Thank you @sche for raising the issue. I've also took a screen shot of a weird back box message that appears when the rejection happens. if you need any more details please let me know. thanks.

@RockmanR thanks for the report. I'm unable to reproduce this. Could you please share the following details?
Hi @tschubotz , based on your questions I figured out the issue. The Ledger was out of gas. When I tried to connect the Ledger through Metamask, Metamask showed me the problem.
It would be great if the the Safe can show that error too, though.
I'll still provide the below information in case it's relevant for the black error box:
Thank you guys.
Hi, thanks for developing this great interface!
I would like to add to this thread that the same issue is happening while creating a new multi-sig with Ledger under the same condition of not having enough ETH on the account.
There is now a proper info about this