Scout: Editable fields on individual level in Cancer view

Created on 30 Jan 2020  路  10Comments  路  Source: Clinical-Genomics/scout

This is similar to the recent change that Chiara added to Scout: Tissue type

  • A solid tumor sample can have sub-types or an more precise tumor-type after analysis. The idea is to be able to either add a new tumor-type to the list of tumor-types or just change it to a completely new value: 1. List of tumor-types can be extracted from TCGA or NCI or OMIM. 2. Cell abnormality type: https://www.ebi.ac.uk/ols/ontologies/ncit/terms?iri=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C12913&viewMode=All&siblings=false
    Tumor_type is a bit vague at the moment, and it might be worthwhile to review this with correct terminology (abnormal cell types).

  • Tumor purity: tumor purity estimate from order form can be forwarded to Scout. However, secondary analysis or post order form additions are possible. It might be useful to be able to update this value as well.

I talked to Chiara about this, and one solution of adding tumor-type, cell-type, etc can be to add them to list of constants.

I'll followup with more details as soon as I get more feedback.

Under discussion Cancer

Most helpful comment

Just to make my previous comment clear, I might have written it hastily: we are discarding 90/90 format and using a decimal format instead, e.g. 0.3.

Ok, I'll fix the demo case as well then!

All 10 comments

See #1581

I could start with this today!

  • [ ] Editable tumor purity is a number in the range 0.1 - 0.9. Alert if it's less than 0.2
  • [x] Editable tissue
  • [x] Normal should have tumor type as N/A
  • [ ] Editable tumor type

@hassanfa question: now tumor purity is saved as a fraction, example 90/90, should it be converted to a number? But it can't be one because max is 0.9, suggestions?

That's cellularity: Tumor cell/Total cell ratio. It can be shown as a ratio or percentage that we discussed. So a 90/90 means 1, or 30/90 means 0.3 (30% purity)

Let's have it as what we discussed: 0.1-1 for editable field. I know I said 0.9, but can we please have it 1? Thanks.

Just to make my previous comment clear, I might have written it hastily: we are discarding 90/90 format and using a decimal format instead, e.g. 0.3.

That's cellularity: Tumor cell/Total cell ratio. It can be shown as a ratio or percentage that we discussed.

Let's have it as what we discussed: 0.1-1 for editable field. I know I said 0.9, but can we please have it 1? Thanks.

Ok!

Just to make my previous comment clear, I might have written it hastily: we are discarding 90/90 format and using a decimal format instead, e.g. 0.3.

Ok, I'll fix the demo case as well then!

Or not?, do you still want to save it as 90/90 in the database, or 1?

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