Broken on new mainline builds with a few issues. I think it happened in the past week or two. Clearing caches doesn't help.
Issues:
1) Soft locks frequently on the long load screen. 50/50 if it makes it to 100% load, where as before this was a sure thing.
2) [Update: Workaround available] When it does makes it past the loading screen, it will always crash if using Vulcan trying to load gameplay with this:
F {rsx::thread} class std::runtime_error thrown: Assertion Failed! Vulkan API call failed with unrecoverable error: Device lost (Driver crashed with unspecified error or stopped responding and recovered) (VK_ERROR_DEVICE_LOST) (in file c:projectsrpcs3rpcs3emursxvkVKHelpers.h:1083)
3) [Update: Improved] On OpenGL, you get into gameplay but will run at only 2 fps.
Working fine before:
https://forums.rpcs3.net/thread-197776.html
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UPDATES:
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Config:
Windows 10 64-bit
GeForce GTX 1080
i7-6700k @ 4GHZ
16GB RAM
Build7084 (pr4820) and later can boot USA version unbrokenConan_RPCS3.zip
But performance+ingame image still completely awful
@kd-11 Just FYI, this is still an issue on today's mainline (9/4).
With 7338 its working with Vulkan, but broken colors are still there and its months..
No change here on even a newer build:
OpenGL: 2 fps (not caching related)
Vulkan: Driver error upon entering gameplay
Existing Issue: Missing textures/broken coloring
Vulkan:

OpenGL:

Added another update to initial post.
it fix the game in this build or not ?
Not quite. It still soft locks half the time on load and OpenGL only runs at half speed. The latter is not that big of a deal since Vulkan is full speed, so you can workaround this (like issue #2). Updated first post.
did it fix it in https://github.com/RPCS3/rpcs3/issues/5708 ?
Updated to cross out #2 and #3. Only Issue #1 persist which is where it'll freeze sometimes while loading data on this screen.

Seems fixed now. 6/6 boots in a row without a hang.
Most helpful comment
1 still the same - 50/50 soft lock on launch
2 is fine with the workarounds
3 OpenGL is 15 fps still (might have always been that way though)