Observed in Lutris Beta 2.
I will use this portion of configuration menu as an example, but please note that this occurs throughout whole configuration menu:

Personally, I think bigger spacing between options is more appealing.
I think 12 pixels would be good. Also, the text for "Path to the game's executable, for x360ce support" should be reduced by moving part of the information (for x360ce support) to a tooltip.
6 is the recommended spacing between elements and 18 between sections:
This is caused by the labels going over 2 lines, I've reduced this by increasing the label width but it still happens in some case an cannot really be avoided.
Most helpful comment
6 is the recommended spacing between elements and 18 between sections: