Due to the change made in https://github.com/xamarin/Xamarin.Forms/pull/1976 for Xamarin.Forms 3.0, ResourceDictionaries that were compiled with XF 2.4 fail to load throwing the following exception:
Can't resolve the reference 'System.Func`2
In particular, the ResourceDictionary in this case contains the styles for custom Xamarin.Forms controls that have a minimum support Xamarin.Forms version of 2.4
Download the simple repro using the link at the bottom of this post. Let me walk you through the two solutions:

This is very simple class library that contains one class, CoolGrid, that inherits from Xamarin.Forms.Grid.
public class CoolGrid : Xamarin.Forms.Grid
{
public CoolGrid()
{
this.Resources = new CoolGridTheme();
}
}
The ResourceDictionary, "CoolGridTheme.xaml", is also very simple and contains a couple OnPlatform for height and a Style to set CoolGrid's BackgroundColor
<OnPlatform x:TypeArguments="x:Double" x:Key="Height" Default="32">
<On Platform="Android" Value="45"/>
<On Platform="iOS" Value="36"/>
<On Platform="UWP" Value="32"/>
</OnPlatform>
<OnPlatform x:TypeArguments="x:Double" x:Key="MinimumHeight" Default="33">
<On Platform="Android" Value="28"/>
<On Platform="iOS" Value="28"/>
<On Platform="UWP" Value="33"/>
</OnPlatform>
<Style x:Key="BaseCoolGridStyle" TargetType="customControls:CoolGrid">
<Setter Property="HeightRequest" Value="{StaticResource Height}"/>
<Setter Property="MinimumHeightRequest" Value="{StaticResource MinimumHeight}"/>
<Setter Property="BackgroundColor" Value="DarkGray"/>
</Style>
The compiled result was copied to the Libs folder in the 2nd solution's folder.
This solution contains the Xamarin.Forms 3.0 projects (_created using the File > New > Xamarin.Forms app > Blank App template and only kept Android to keep it small_).
I updated the XF NuGet page to the latest public release and added the reference to the CustomControls assembly in the Libs folder.
Finally, on MainPage, I add a single instance of CoolGrid:
<ContentPage xmlns="http://xamarin.com/schemas/2014/forms"
xmlns:x="http://schemas.microsoft.com/winfx/2009/xaml"
xmlns:customControls="clr-namespace:CustomControls;assembly=CustomControls"
x:Class="ResLoaderRepro.MainPage">
<StackLayout>
<customControls:CoolGrid x:Name="MyCoolGrid" HeightRequest="100" WidthRequest="100"/>
</StackLayout>
</ContentPage>
Here's a screenshot to better explain the simplicity of the setup:

The CoolGrid control will render.
An exception is thrown (see scrrenshot 4 below
System.MissingMethodException: System.Func`2
Here's a screenshot of the break:

Screenshots inline with the explanation above.
https://github.com/xamarin/xamarin-macios/issues/3639
The solution here
https://bugzilla.xamarin.com/show_bug.cgi?id=60949
Was just to downgrade but that doesn't seem to work in your case
I also converted your project to netstandard since it was .net 4.5 just to see and same issue
Any chance for quick fix? It's blocking me from updating my app to any Xamarin.Forms greater than 2.5.1.527436...
I'm literally investigating this right now, but still can't tell if we'll be able to deliver a fix, nor can't I give you a time frame.
The workaround is to make sure all your dependencies are compiled against latest XF 3.0.0
I can confirm https://github.com/xamarin/Xamarin.Forms/pull/2880 fixes the problem in my tests (attached repro and commercial 3rd party libraries).
Repro Screenshot (using new Xamarin.Forms package containing fix):

@LanceMcCarthy could you also confirm it works on iOS ? thanks
@StephaneDelcroix confirmed working on iOS 11.4, iPhone 8

Hi @StephaneDelcroix , do you know when the next release will be with this fix? Thank you.
@avintoptaros It looks like the fix is already included in the release-3.0.0-sr3 and beta-3.1.0-pre3.
@stephanosio I see that on the release page there is no release-3.0.0-sr3 version (https://developer.xamarin.com/releases/xamarin-forms/xamarin-forms-3.0/)
@avintoptaros Try this: https://github.com/xamarin/Xamarin.Forms/releases
Most helpful comment
Any chance for quick fix? It's blocking me from updating my app to any Xamarin.Forms greater than 2.5.1.527436...