Im unable to open study/series via URL pattern http://

If you go to http://
e.g. https://stackoverflow.com/questions/7027636/nginx-send-all-requests-to-a-single-html-page
If you go to http://
do you get the study list? If so I guess it's a setting for your IIS server. You need to redirect all paths which do not exactly match files in the directory to index.html. Similar setting exist for e.g. AWS S3, Google Cloud Storage Buckets, or Nginx when you are using them for hosting single-page applications. e.g. https://stackoverflow.com/questions/7027636/nginx-send-all-requests-to-a-single-html-page
Yes I do get the study list when I go to http://
You suggestion was exactly what was required. The following link helped setup the rewrite rules in IIS:
https://www.mattburkedev.com/iis-rewrite-rule-for-single-page-apps/
Great!