In Firefox, when I switch to reader view, images that should be blocked by uBO's no-large-media: * true are not blocked.
https://jotter.jonathankingston.co.uk/blog/2017/04/04/containers-assignment/
Dev tools - network panel of the regular page: browser connects but doesn't download

Logger of the regular page:

Dev tools after hitting Reader view icon: browser reconnects and downloads content

Logger of the page after hitting Reader View icon

no-large-media: * true ruleEDIT: I just noticed that the extension is fully disabled in Reader View (the uBO icon in the toolbar turns grey) so it seems this isn't an issue specific to images. This may be a browser imposed limitation. Am still posting in case I'm wong.
uBO is disabled because the context is reader.about-scheme, and uBO is whitelisted by default for about-scheme. It works fine if un-whitelisted.
Thinking more about it, I will try to see if I can provide the current context in the tooltip of uBO's power button, there is currently no obvious way to find out the current context was reader.about-scheme (have to go through the logger).
as per earthlng's comments here
matrix-off: about-scheme false
about-scheme * * allow
reader.about-scheme * * block
reader.about-scheme * image allow <==edited/added since post
there is currently no obvious way to find out the current context was
reader.about-scheme
Actually there is now, since the new popup panel was introduced in 1.27.0
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Thinking more about it, I will try to see if I can provide the current context in the tooltip of uBO's power button, there is currently no obvious way to find out the current context was
reader.about-scheme(have to go through the logger).