This doesn't work for me:
route = sf::read_sf("https://git.io/fhnA2")
tm_shape(route) +
tm_lines(col = "blue")
This - with no Z component, works:
route = sf::read_sf("https://git.io/fhnAr")
tm_shape(route) +
tm_lines(col = "blue") +
tm_shape(location$osm_polygons) +
tm_polygons(fill = "red")
Hope this is of use - apologies if I've missed something.
Hmm, both examples give

Did you get errors or the wrong output?
Aha - it's only when in view mode. Reprex this time:
library(tmap)
route = sf::read_sf("https://git.io/fhnA2")
tm_shape(route) +
tm_lines(col = "blue")
#> Linking to GEOS 3.5.1, GDAL 2.1.2, PROJ 4.9.3

ttm()
#> tmap mode set to interactive viewing
tm_shape(route) +
tm_lines(col = "blue")
#> Error in if (length(nms) != n || any(nms == "")) stop("'options' must be a fully named list, or have no names (NULL)"): missing value where TRUE/FALSE needed
Created on 2019-01-14 by the reprex package (v0.2.1)
Session info
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I partly traced back the problem:
route = sf::read_sf("https://git.io/fhnA2")
# works
mapview(route)
# doesn't work
leaflet() %>% addPolygons(data=route)
It seems mapview fixes some problem, similar the to issue of having a named sfc. (@tim-salabim)
In mapview I use the equivalent of leaflet() %>% addPolygons(data=sf::st_zm(route)) which effectively removes all z and/or m values from the coordinates.
See:
https://github.com/r-spatial/mapview/blob/develop/R/extensions.R#L675
Most helpful comment
In mapview I use the equivalent of
leaflet() %>% addPolygons(data=sf::st_zm(route))which effectively removes all z and/or m values from the coordinates.See:
https://github.com/r-spatial/mapview/blob/develop/R/extensions.R#L675