In Sins of the Father on Dantes Inferno, the axe on the bull's hand doesn't answer properly when triggered, making impossible to move on, since is a key element on the game.
You can see this issue on this video https://www.youtube.com/watch?v=rhVlogL4_aU
I tested many settings and its the same result.
I'm attaching the save file if someone is willing to test it.
Settings used:
https://www.youtube.com/watch?v=sPS9xRIqVQw
RPCS3 Dantes Inferno Save File.zip
I found and work around, it does not solve the physics issue, but allow you to progress on the game without using the mechanism, if someone wants, I can do a video showing it.
Finished the game using the work around I found.

I'm attaching the save data with the game complete in case you want to start a new game with skipable cutscenes.
But the issue persists, I just found a way to go around it. So technically this should be keep open until it get fixed properly.
Here it goes the work around with the physics issue:
Part 1:
https://www.youtube.com/watch?v=KKE9EPn7SmU
Part 2:
https://www.youtube.com/watch?v=issSi8wJ80o
I'm attaching the closest save point after doing the work around for who doesn't want to bother doing the work needed to get through on this part.
This is still not resolved, I just got to this part and have the same issue. Will try the work around, but yeah, the bug is still present.
Still present in most recent master version.
GPU - 03G-P4-2888-KR
F {RSX [0x07f6614]} RSX: class std::runtime_error thrown: Invalid location (offset=0x191f700, location=0xc)
(in file c:projectsrpcs3rpcs3emursxrsxthread.cpp:101)
This issue is still exist on last release version
Look's like Eladash's latest fixes fixed not only MGS4, huge demon statue bug is also fixed now, the game is playable

Fantastic news, thanks for the update. Guess we can close this and update the compat. list.
Some people still said there were audio issues, so need to make sure its running well for the majority of users before we classify it as playable. But yeah, good news 馃憤
If you count audio issues as blockers, i'm sure many games will regress into ingame category. There are many issues like overtime audio choppiness etc that affects whole emulator , not a handful of games.
When this problem is solved, the game can be fully playable , I have cleared this game completely .
I'd be more concerned about the game randomly crashing really.
Move this discussion to forums, the core issue here is fixed.
Most helpful comment
Move this discussion to forums, the core issue here is fixed.