I know its a minor thing, but would it be possible to bring it back?
It's working in the Main window but it looks like this is not working in GSframe.
We'll look into it.
I think the buttons are disabled when the main window lose focus.
In wx the Pause,stop and restart buttons are still enabled when main windows lose focus

In QT the Pause,Stop and restart buttons grey out on losing focus

The GSFrame does not seem to be recognized as an application window so I can't use the normal flag that would keep those shortcuts enabled.
Considering eventhandling
Edit: should be fixed in referenced PR
Fixed on #2834
Because everybody like you now has every time the game stops when you press the block + back, namely, Ctrl + s in the classic PC running the game Demon's Souls, and spam constantly shuffles the full-screen mode change to the window and back
Golden shovel of issue digging...
That's why people who don't want to sit on their desk all day especially after work play using gamepads.
But I can see how this might be annoying. If I ever have the time i'll add some shortcut management (very low priority)
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Because everybody like you now has every time the game stops when you press the block + back, namely, Ctrl + s in the classic PC running the game Demon's Souls, and spam constantly shuffles the full-screen mode change to the window and back