React-native: Remote Debug in Prod mode after 0.58

[in4core]

Remote Debug JS - works only DEV mode after 0.58 , but in 0.57 all good.
When starts it in Prod mode we have some errors
Cannot read property 'Constants' of null
Module AppRegistry is not a registered callable module (calling runApplication)

React Native Environment Info:
System:
OS: Windows 10
CPU: (4) x64 Intel(R) Core(TM) i5-4690K CPU @ 3.50GHz
Memory: 1.68 GB / 7.95 GB
Binaries:
npm: 6.7.0 - C:Program Files\nodejs\npm.CMD
IDEs:
Android Studio: Version 3.3.0.0 AI-182.5107.16.33.5199772

Dependencies :
"dependencies": {
"react": "16.6.3",
"react-native": "0.58.3",
"react-native-gesture-handler": "^1.0.15",
"react-native-img-cache": "^1.6.0",
"react-native-section-list-get-item-layout": "^2.2.3",
"react-native-vector-icons": "^6.2.0",
"react-navigation": "^3.0.9",
"rn-fetch-blob": "^0.10.15"
},

[react-native-bot]

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[axlider]

I had the same Problem running on Device Android.
In my case I had "Debug JS Remotely" activated and "JS DEV Mode" deactivated (Developer Menu).
When I activated "JS DEV Mode" the error message vanished.
I am observing this since RN version 0.57.

[xSmoggeRx]

I get same error here. I'm running RN version 0.59.9