OS: Fedora 30 with KDE Plasma
qTox version: v1.16.3+
Commit hash: 48d23234b7b34b1a8c750b75f6510f5b30def4be
toxcore: 0.2.10
Qt: 5.12.5
Hardware: Desktop
Reproducible: Always
The qTox window opens, but the entire windows is blank:

The window restores correctly.
"Minimize to tray" functionality works correctly. This issue isn't reproducible on Ubuntu 19.04 with gnome.
Credit to @TheDcoder for first identifying the issue in https://github.com/qTox/qTox/issues/5846#issuecomment-544233302.
I just want to note that this issue doesn't seem to be effecting the AppImage, I have been using the latest stable AppImage since a few weeks and I never observed this issue.
(Same OS - Fedora 30 with KDE)
Fedora 30 KDE with the AppImage (v1.16.3) here; no such problem either.
qBittorrent had a similar issue recently (fixed in qbittorrent/qBittorrent#10590), and it seems to be related to the QCloseEvent class. The AppImage probably works because it comes with an older version of Qt.
The same problem exists in Gentoo with net-im/qtox-1.16.3, dev-qt/qtgui-5.12.5 and kde-plasma/plasma-desktop-5.16.5.
Most helpful comment
Fedora 30 KDE with the AppImage (v1.16.3) here; no such problem either.
qBittorrent had a similar issue recently (fixed in qbittorrent/qBittorrent#10590), and it seems to be related to the QCloseEvent class. The AppImage probably works because it comes with an older version of Qt.