PTVS 2.2.1 (2.2.31007.01)
VS 2015 Update 1 RC 24606.01
Python 3.5 64-bit virtual env
Bottle project
Put breakpoint in routes.py about() method
F5 with Microsoft Edge browser selected
Browse to about page
You'll see this:

Debug interactive works, but call stack doesn't appear (see pic).
It's a VM with defaults for everything in VS, except for auto-indent set to None for Python.
Just my Code setting doesn't make a difference.
Also, debugging small Python console app in 3.5 64-bit virtual env worked fine.
Bug went away in VS 24613.01 & PTVS 2.2.31014.03
Could anyone remove the stupid "Break mode" page??
Most helpful comment
Could anyone remove the stupid "Break mode" page??