Can't update any backend settings, like the Mail Configuration for example, but not only.
Receiving this "403 Forbidden" error
My plugin settings page is working fine, and other plugin settings are working fine as well.
It seems like only the October CMS Settings are not updatable.
OC Fresh install on a Digital Ocean instance.

Possibly related to https://octobercms.com/support/article/ke-1, if you have weird ModSecurity rules enabled it could be blocking that request specifically.
thanks @LukeTowers
I had to disabled entirely ModSecurity to make the backend settings works.