As noted on this toot, Mastodon's default style is not accessible to all. There are technical work-arounds (userstyles and such), but they may imply the help from other people or a certain technical knowledge to be useful.
An option to a higher-contrast, higher-visible interface would be nice, especially if offered from the get-go through the welcome screens.
Reference: https://computerfairi.es/users/maunzikation/updates/2884
This should definitely be added in when there's a theme engine available (see #2028)
This could be added with #1587 too.
Reviving this thread to note that in the default theme, the text "Information below may reflect the user's profile incompletely. View full profile" is still too low-contrast.

High contrast theme has been added recently in #7213