After upgrading to 2.2.4, we lost all our Thai subject lines. We are forced to put them in English for the time being.
This issue is also reproduced in Magento 2.2.3 with greek characters.
I confirm this issue too, in 2.2.3.
Before change any record from Marketing -> Email Templates, the records in the database is ok, but in the grid all subject's characters that are note latin (i.e. Greek letters) appear as the issue "Actual result".
After change any record, this record saved as the issue "Actual result" in the database too.
This is also true for the characters out of {{trans }}
(i.e. "ΑΒΓΔΕ{{trans ΑΒΓΔΕ}}" --> "?????{{trans ?????}}")
same in 2.2.5
Hi @jsdupuis the fix for this issue has already been in 2.2-develop branch

Issue doesn't related to Magento code. Can be reproduced even on the 2.2-develop, if you enable Dotmailer extension.
INFO:
Caused by vendor/dotmailer/dotmailer-magento2-extension/Plugin/TemplatePlugin.php
LINES: 103-105
...
if ($field == 'template_subject') {
$result = utf8_decode($result);
}
...
Any solution got for this issue? this issue is still present in 2.2.6
Most helpful comment
Issue doesn't related to Magento code. Can be reproduced even on the 2.2-develop, if you enable Dotmailer extension.
INFO:
Caused by vendor/dotmailer/dotmailer-magento2-extension/Plugin/TemplatePlugin.php
LINES: 103-105