In iTerm 2, if we enable option 'Applications in terminal may access clipboard':

Then in tmux, the copy mode can copy content to system clipboard, not just tmux's own clipboard. This is a very useful feature to me. It would be nice if hyper can also support this.
Currently it is not possible to use mouse input to copy and paste. Which for me copying and pasting using Hyper with Tmux is pretty much impossible. To note using the keyboard C-a [/v/y would work.
@DeciderWill I use tmux and can alt+click to copy on mac with https://github.com/zeit/hyper/issues/3592#issuecomment-492163239
Most helpful comment
Currently it is not possible to use mouse input to copy and paste. Which for me copying and pasting using Hyper with Tmux is pretty much impossible. To note using the keyboard
C-a [/v/ywould work.