I鈥檓 developing a physics game, and I make levels in Defold IDE. Each level is a collection with many pre-made game objects (obstacles, enemies, bonuses, walls). It鈥檚 a very convenient way to make levels because I can preview my levels right in the IDE and I don鈥檛 have to spend my time to make a special level editor.
How it looks:

My game will have 250+ levels. I made 60 levels, and it鈥檚 a pain to make more.
IDE is very slow when there are many collections
For example, you can try to change something or to edit the main.script, i.e. even entering new text is lagging on my PC for 0.5-1 sec. PC has 8 core Ryzen 2700X.
Demo project:
lot_of_collections1.zip
+1
https://twitter.com/deulamco/status/1345740345900900352
| Build time | 2020-12-18T20:28:49.967999 |
| Defold channel | editor-alpha |
| Defold editor sha | 15990df1280c63c1744849d6456237c6411f593e |
| Defold engine sha | f7778a8f59ef2a8dda5d445f471368e8bd1cb1ac |
| Defold version | 1.2.177 |
| GPU | GeForce GTX 1080 Ti/PCIe/SSE2 |
| GPU Driver | 4.6.0 NVIDIA 460.89 |
| Java version | 11.0.1+13 |
| OS arch | amd64 |
| OS name | Windows 10 |
| OS version | 10.0 |
Most helpful comment
I've bumped into this issue too. In layman's terms, the slowdown happens when the file edited is used in many other places. In my case, object.script exists in every object in the game, and the game has 100 levels. Editing object.script in Defold is very slow, so I have started editing it in an external editor, then coming back to Defold and wait for the changes to propagate.