If I make changes to docker-compose.yml, such as command, these changes are not picked up automatically when using docker-compose run. 
I'm able to force it to detect these changes by using docker-compose down -v --remove-orphans. 
Any ideas why this isn't automatically applied?
Never mind, this is because run does not detect changes but up will
Weird, I also made some changes to docker-compose.yml, tried running docker-compose up but the changes did not get picked up.
The changes are:
ADD nginx_app.conf /etc/nginx/sites-enabled/
CMD systemctl reload nginx
@NinoSkopac If you make changes to your Dockerfile, you'll need to run docker-compose build again.
$ docker-compose build --help
Build or rebuild services.
Services are built once and then tagged as `project_service`,
e.g. `composetest_db`. If you change a service's `Dockerfile` or the
contents of its build directory, you can run `docker-compose build` to rebuild it.
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Never mind, this is because
rundoes not detect changes butupwill